New: Our latest case study on qFibrosis' role in the successful development of Rezdiffra

Intelligent Biophotonics for Fibrosis Assessment

Unlocking Deeper Insights in Digital Pathology

We are pioneering the future of digital pathology through our proprietary AI-powered platform. Using breakthrough second harmonic generation microscopy and machine learning algorithms, we provide unprecedented insights into biological tissues for drug development and precision medicine.

Fibrosis Quantification for MASH and MAFLD

Stain-free Solution

Our Genesis®200 Imaging System uses label-free second harmonic generation (SHG) microscopy to visualize fibrillar collagen in tissue biopsies in incredible detail without limitations of conventional staining. Our Powerful HistoHepa© AI algorithm then extracts quantitative, reproducible digital biomarkers to inform decision making. By combining SHG imaging with cloud-based analytics, we offer turnkey digital pathology that consistently reveals subtleties within tissues are difficult to perceive using conventional staining procedures.


Leverage quantitative and objective metrics to accurately stage disease


Visualize subtle changes in microstructure to assess therapeutic response


Improve inter- and intra-observer agreement in the study of complex diseases


Obtain a 360° complete understanding to inform decisions

Second Harmonic Generation Microscopy

Laser-based Collagen Imaging

SHG Image of Fibrosis in a Liver Biopsy. Collagen in Green, Hepatocytes and Immune Cells in Red
SHG Image of a Liver Biopsy. Collagen in Green, Hepatocytes and Immune Cells in Red

SHG imaging is a technique that involves a femotosecond laser interacting with non symmetrical structures within tissues to produce photons at half the wavelength of the excitation. This highlights biological structures and subtle changes within tissues in stunning detail. Compared to conventional staining and methodology, SHG offers:

  • 2D/3D imaging of tissues without exogenous stains
  • Enhanced visualization of collagen fibers at high resolution
  • Non-destructive imaging of unstained tissue

Extensive Applications Across Diseases

Fibrotic Diseases

  • Liver Fibrosis
  • Renal Fibrosis
  • Pulmonary Fibrosis
  • Bone Marrow Fibrosis
  • Dermal Fibrosis
  • Sub-epithelial Fibrosis on Cornea
  • Retinal Pigment Epithelium
  • Arterial Fibrosis
  • Cardiac Fibrosis
  • Biliary Disease
  • Muscular Dystrophy (Sarcopenia)
  • Alcoholic Liver Disease
  • Alpha-1 antitrypsin Deficiency 
  • Biliary Atresia


  • Breast Cancer
  • Pancreatic Cancer
  • Liver Cancer
  • Lung Cancer
  • Ovarian Cancer
  • Colon Cancer
  • Kidney Cancer
  • Bladder Cancer
  • Squamous Cell Carcinoma of the Head and Neck (SCCHN)

Measuring specific collagen parameters in Fibrosis

qFibrosis Liver Biopsy Assessment

qFibrosis® is an automated, quantitative technique to evaluate liver fibrosis in patients with Metabolic Dysfunction-associated Fatty Liver Disease (MAFLD) and Metabolic Dysfunction-associated Steatohepatitis (MASH). Developed with experts, qFibrosis

  • provides quantitative and continuous measurements
  • has greater sensitivity to regression
  • allows localized zonal assessment
  • is a multi-parametric approach
  • Digitizing Healthcare

    Through evidence-based studies, we are pushing the boundaries to algorithmize decision-making from drug development to precision diagnosis, to prediction of disease progression, and subsequently, life-changing therapies personalized to each patient. Discover how our stain-free, AI digital pathology platform can support your objectives.